Genomic distribution of Glucocorticoid Receptor binding sites (GBS) upstream of the Tyrosine Hydroxylase gene (TH). Two significant peaks representing GR-binding are observed at approximately 5.7 kb (peak 1) and 19.7 kb (peak 3) upstream of the transcription start site (TSS) as indicated by arrows. The 5.7 kb GBS was previously described in PC12 cells transfected with the TH promoter . A third peak (peak 2) upstream of the TH gene was apparent, but was not significantly above background (IgG signal) at this position, so was not further analysed. Data was visualized with the UCSC genome browser .