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Figure 4 | BMC Neuroscience

Figure 4

From: The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2

Figure 4

Dicholine succinate reduces stress-induced floating and anxiety-like behaviors, but not a decrease of body weight. (A) Latency of floating had an overall significant difference for treatment while the duration of floating had an overall significant difference for the stress condition F = 4.652, DFn = 2, DFd = 89, p = 0.0120 and F = 5.333, DFn = 1, DFd = 89, p = 0.0232 respectively two-way ANOVA; * vs non-treated, # vs respected controls. (B) ANOVA revealed a significant difference for time spent in the lit compartment with Tukey showing only a difference between the Not and DS treated stress groups F = 4.469, DFn = 3, DFd = 39, p = 0.0086, Tukey p < 0.01 ;*vs respected control. No significant difference in latency of exit was observed. (C) Two-way ANOVA revealed a significant difference in body weight for the stress condition in all groups F = 66.81, DFn = 1, DFd = 89, p < 0.0001. * vs respected controls NoT: non-treated group; Imi: imipramine-treated group, DS: DS-treated group. All data is shown as mean ± SEM.

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BMC Neuroscience

ISSN: 1471-2202

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