Figure 2
From: Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons
5-HT-mediated inhibiton of Ip is mediated by 5-HT 3 R, but not by 5-HT 1A R in hippocampus. (A) The representative tracing of 0.5 mM Str- mediated Ip in the control. (B) The representative tracing of 5-HT (0.1 mM) -mediated inhibiton of Ip. WAY100635, a 5-HT1AR antagonist, alone did not affect Ip (P > 0.05) (C), and did not block 5-HT-mediated inhibiton of Ip (D). Ondasetron, a 5-HT3R antagonist, alone did not affect Ip (P > 0.05) (E), whereas attenuated 5-HT-mediated inhibiton of Ip (F). (G) 5-HT-mediated inhibiton of Ip is blocked by ondasetron, but not WAY100635. (H) The representative tracing of m-CPBG (0.1 mM)-mediated inhibiton of Ip. (I) m-CPBG (0.1 mM) -mediated inhibiton of Ip. Values significantly different by Student's t-test from results are indicated as **P < 0.01.