Model structure and simulation results. A. Overview of the model showing retina, LGN, and a cortical microcircuit with cell types. B. Orientation preference map for neurons in layer 4. C. Network response to a moving bar visual stimulus. D. Snapshot of a simulated “voltage sensitive dye” image of the activity in layer 2/3, in response to a stationary bar stimulus, illustrating a “virtual experiment” in the model.