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Figure 1 | BMC Neuroscience

Figure 1

From: Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

Figure 1

Distribution of Asb-4 and IRS4 mRNAs in the rat brain. Photographs are representatives of 15 brain sections from 5 animals for each hybridization. [35S]- labeled antisense or sense RNA probes were used for in situ hybridization. A. Antisense Asb-4 RNA probe. Scale bar = 1.0 mm. B. Antisense IRS4 RNA probe. C. Sense Asb-4 RNA probe. D. Sense IRS4 RNA probe. E. Dark field photomicrograph of Asb-4 mRNA in ARC. Scale bar = 0.5 mm. F. Dark field photomicrograph of IRS4 mRNA in ARC. ARC, arcuate nucleus; DMN, dorsomedial nucleus; LH, lateral hypothalamic area; VMH, ventromedial nucleus; Amyg, amygdala. 3V, third brain ventricle.

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BMC Neuroscience

ISSN: 1471-2202

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