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Figure 7 | BMC Neuroscience

Figure 7

From: Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors

Figure 7

Model of the proposed pathway by which extracellular ATP activates NFAT in PC12 cells. The results demonstrate the requirement of Ca2+ influx from the extracellular space and the contribution of both calcineurin-NFATc and MEK-ERK1/2 pathways. The scheme also illustrates the inhibitors used for pharmacological characterisation. BTP2 is a blocker of SOCE and inhibits TRPC channels, but its direct molecular target in PC12 cells is not clear.

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