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Figure 9 | BMC Neuroscience

Figure 9

From: Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury

Figure 9

Altered XIAP and cIAP-1 mRNA expression in mutant mice with altered IGF-I expression. A. Representative Northern blot analysis of XIAP and cIAP-1 mRNA in cerebral cortex (CTX) and hippocampus (HIP) from an IGF-I transgenic mouse and a littermate control at postnatal day (P) 20. IGF-I transgenic mouse is indicated with + at top of lanes. Cyclophilin (CYC) signals and image of methylene blue staining of 18S rRNA (18S rRNA) were shown as bottom two panels, respectively. B. Quantification of XIAP and cIAP-1 mRNA in developing CTX and HIP of IGF-I transgenic mice. C. Representative Northern blot analysis of XIAP and cIAP-1 mRNA in HIP from a P20 igf-I-/- mouse (IGF-I KO) and a control mouse. D. Quantification of XIAP and cIAP-1 mRNA in the CTX and HIP P20 igf-I-/- mice and their littermate controls. In both panels B and D, values represent mean ± SE from 4 - 6 brains in each group. *, p < 0.05; **, p < 0.01, compared to control mice.

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