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Table 1 Significantly populated KEGG signaling pathways created by genes differentially regulated between learners and swimmers

From: Cortical gene transcription response patterns to water maze training in aged mice

KEGG Category

Transcripts

Fold change

p-value

MAPK signaling

brain derived neurotrophic factor

1.4041

0.0063

 

growth arrest and DNA-damage-inducible 45 alpha

1.2334

0.0000

 

dual specificity phosphatase 1

1.6577

0.0005

 

RAS related protein 1b

1.2067

0.0306

 

activin A receptor, type IC

1.3618

0.0000

 

dual specificity phosphatase 14

1.1473

0.0035

 

serine/threonine kinase 4

1.1598

0.0316

 

dual specificity phosphatase 6

1.5402

0.0000

Focal adhesion

catenin (cadherin associated protein), beta 1

1.2247

0.0051

 

cyclin D1

1.4578

0.0019

 

integrin beta 5

1.1444

0.0365

 

3-phosphoinositide dependent protein kinase-1

1.1971

0.0211

 

protein phosphatase 1, catalytic subunit, beta isoform

1.3220

0.0193

 

RAS related protein 1b

1.2067

0.0306

Actin cytoskeleton

integrin beta 5

1.1444

0.0365

 

myosin, heavy polypeptide 9, non-muscle

1.3739

0.0061

 

protein phosphatase 1, catalytic subunit, beta isoform

1.3220

0.0193

 

NCK-associated protein 1

1.1491

0.0427

 

actin related protein 2/3 complex, subunit 5

  

Insulin signaling

3-phosphoinositide dependent protein kinase-1

1.1971

0.0211

 

protein phosphatase 1, catalytic subunit, beta isoform

1.3220

0.0193

 

insulin receptor substrate 2

1.3744

0.0229

 

protein phosphatase 1, regulatory (inhibitor) subunit 3C

1.2373

0.0329

Wnt signaling

catenin (cadherin associated protein), beta 1

1.2247

0.0051

 

cyclin D1

1.4578

0.0019

 

protein phosphatase 2, regulatory subunit B, gamma isoform

1.2332

0.0396

 

protein phosphatase 2, regulatory subunit B, beta isoform

1.2616

0.0191

  1. The table indicates the most significantly populated KEGG pathways and the corresponding genes from the input dataset (significantly regulated in learners versus swimmers) that were clustered into the respective pathways.