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Figure 3 | BMC Neuroscience

Figure 3

From: An evolutionary conserved region (ECR) in the human dopamine receptor D4 gene supports reporter gene expression in primary cultures derived from the rat cortex

Figure 3

Sp1 represses the D4ECR1 expression in dissociated cultures of neonate rat frontal cortex. Transcriptional activities of D4ECR1 and control plasmid (pGL3p) were equalled to 100%. Both D4ECR1 and pGL3p plasmids were co-transfected with 2 concentrations of Sp1 expression vector (0.5 and 1 μg). Sp1 significantly down regulated transcriptional activity supported by D4ECR1 (Student's T-test p ≤ 0.01 = **; n = 9, 2 day old neonates). The effect of Sp1 over-expression was expressed as the percentage repression on basal transcriptional activity of D4ECR1 and pGL3p.

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BMC Neuroscience

ISSN: 1471-2202

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