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Table 1 Proteomic identification of dysregulated proteins in SMN-deficient ES cells

From: Proteomic assessment of a cell model of spinal muscular atrophy

Protein Name Gene Symbol Fold Change Function
Undifferentiated    
   Chaperonin 6a Cct6a +2.6 Protein folding
   FK506 binding protein 4 Fkbp4 +1.75 Protein folding and trafficking
   Peroxiredoxin 6 Prdx1 +1.6 Redox regulation
   Stress-induced-phosphoprotein 1 Stip1 -1.75 Adaptor protein for Hsp70 and Hsp90
Differentiated    
   Lactate dehydrogenase B Ldhb +3.6 Glycolysis
   Brain creatine kinase Ckb +1.8 Cellular energy homeostasis
   Glyoxalase 1 Glo1 +1.75 Detoxification of glucose degradation products
   Tropomyosin 3 Tpm3 +1.75 Stabilization of actin filaments
   Annexin A5 Anxa5 +1.7 Cell signaling, Inflammation; Growth/differentiation
   Ubiquitin carboxy-terminal hydrolase L1 Uchl1 +1.7 De-ubiquitination; Ubiquitin ligation; Mono-ubiquitin stabilizer
   Alpha-tubulin Tuba1a +1.5 Cytoskeletal protein
   Aldehyde dehydrogenase Aldh5a1 -1.7 Aldehyde oxidation
   14-3-3 gamma Ywhag -1.7 Cell signaling; Check point control; Apoptosis
   Heat shock protein 90B Hsp90b1 -1.8 Chaperone protein
   Heat shock protein 70K Hspa9 -2.2 Chaperone protein; Cell proliferation