Tonotopic distribution of tone-induced hair cell damage in the goldfish saccule. Mean (±S.E.) percent hair cell loss as a function of location along the rostral-caudal axis of the saccule for each of the four tone exposures (A, B, C, D = 100, 800, 2000, and 4000 Hz, respectively). Region 1 represents the far rostral area of the saccule and region 7 represents the far caudal area (n = 10-12). Drawings of the distribution of damaged areas on the left saccular macula at the exposure tones indicated are to the right of the appropriate graph. Areas were marked as damaged if they appeared to be missing significant numbers of hair cells when viewed at low magnification (20× objective). Each colored line represents areas of hair cell bundle loss for an individual left saccule (n = 5-6). Similar patterns were found in right saccules.