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Table 3 [3H]-PK11195 binding parameters(a) in mouse membranes.

From: Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouse

Brain:

Kd (nM)

Bmax(fmol/mg protein)

ob/ob Mutant

1.75 ± 0.3

403.5 ± 12.6 (*)

Wild Type

1.8 ± 0.2

329.5 ± 16.0

Kidney:

Kd (nM)

B max (fmol/mg protein)

ob/ob Mutant

1.9 ± 0.2

19550 ± 1180

Wild Type

2.0 ± 0.3

20260 ± 2017

  1. (a): Data are presented as mean ± SD of n = 4 separate experiments in brain and kidney membrane preparations carried out in ob/ob and WT animals as indicated in the Methods sections. (*): Student t- test, p < 0.05.
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BMC Neuroscience

ISSN: 1471-2202

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