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Table 3 [3H]-PK11195 binding parameters(a) in mouse membranes.

From: Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouse

Brain: Kd (nM) Bmax(fmol/mg protein)
ob/ob Mutant 1.75 ± 0.3 403.5 ± 12.6 (*)
Wild Type 1.8 ± 0.2 329.5 ± 16.0
Kidney: Kd (nM) B max (fmol/mg protein)
ob/ob Mutant 1.9 ± 0.2 19550 ± 1180
Wild Type 2.0 ± 0.3 20260 ± 2017
  1. (a): Data are presented as mean ± SD of n = 4 separate experiments in brain and kidney membrane preparations carried out in ob/ob and WT animals as indicated in the Methods sections. (*): Student t- test, p < 0.05.
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