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Table 2 [3H]-paroxetine binding parameters(a) in mouse membranes.

From: Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouse

Brain: Kd (nM) Bmax(fmol/mg protein)
ob/ob Mutant 0.1 ± 0.01 368 ± 17.5
Wild Type 0.09 ± 0.01 341 ± 18.0
Platelets: Kd (nM) B max (fmol/mg protein)
ob/ob Mutant 0.09 ± 0.008 18680 ± 2278
Wild Type 0.08 ± 0.01 14830 ± 1722
  1. (a): Data are presented as mean ± SD of n = 4 separate experiments in brain or platelet membrane preparations carried out in ob/ob and WT animals as indicated in the Methods section.
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