Figure 4

Spatial and time-dependent expression patterns of genes enriched in OCx. Expression profiles for 4 selected genes in rat brain regions, across different stages of the developing cortex, in astrocytes, oligodendrocytes and neurons and in different neuronal subtypes, as well as laminar expression patterns of the regional genes in their corresponding cortical regions. Profiles (a-d) were generated based on microarray data obtained from [20] (a), [10] (b), [28] (c) and [30] (d). Individual samples, including replicates, are placed along the x-axis. The y-axis indicates normalised signal intensities for each gene in each individual sample. Simple profiles are presented for illustration purposes; full profiles with detailed expression levels and sample information are available as additional material. In situ hybridisation images (e) were downloaded from the Allen Mouse Brain Atlas. FMCx, fronto-medial cortex; TCx, temporal cortex; OCx, occipital cortex.; HiF, Hippocampus; Str, Striatum; Cb, cerebellum; Oligo, oligodendrocytes; Astro, astrocytes; Glu, Glutamatergic neurons; GABA, GABAergic neurons; CgCx, cingulated cortex; SSCx, somatosensory cortex; n.a., not available; * arrows indicate increasingly mature cells