Long-term depression (LTD) is disrupted in Kal7KO mice. A) Example traces of evoked fEPSPs before (black) and 30 min after (red) paired-pulse low frequency stimulation (PP-LFS; 3 stimuli/50 ms intervals delivered at 1 Hz for 15 min) for a WT and Kal7KO animal. Calibration bars: 0.1 mV, 20 ms. B) Group time courses for WT and Kal7KO mice showing the fEPSP slope in response to PP-LFS. LTD induction was at time zero (excluded from time course). C) Group data showing the effect of PP-LFS on fEPSP slope 60 min post-induction in WT and Kal7KO animals (n = 8 animals, 2 slices/animal for each genotype). *, p < 0.05 compared to baseline.