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Table 2 Correlation data for candidate genes.

From: Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway

Column1

Gene

Slope

95% Confidence Intervals

Goodness of Fit, R square

P value

n

Ad libitum

Pfn2

0.57

-0.1531 to 1.286

0.29

0.107

10

Chow fed

Ntrk2

0.55

0.1165 to 0.9898

0.52

0.019

10

Mice

Bdnf

-0.47

-0.7881 to -0.1488

0.63

0.011

10

 

Prkacb

-0.06

-0.3902 to 0.2681

0.02

0.680

10

 

Vamp2

0.29

-2.319 to 2.905

0.01

0.793

8

 

Stat3

0.50

-1.635 to 2.626

0.05

0.590

8

 

Nln

0.63

-1.469 to 2.737

0.08

0.489

8

 

Btbd12

2.38

-3.681 to 8.433

0.13

0.374

8

 

Zbtb20

2.29

-1.129 to 5.710

0.31

0.152

8

 

Atf7ip

-

-

-

-

-

Food deprived

pfn2

1.19

0.2082 to 2.171

0.66

0.026

8

mice

Ntrk2

0.09

-0.54 to 0.73

0.03

0.724

8

 

Bdnf

0.06

-52 to 0.64

0.02

0.792

8

 

Prkacb

-0.04

-1.198 to 1.113

0.00

0.932

8

 

Vamp2

0.71

-0.5620 to 1.983

0.24

0.221

8

 

Stat3

0.54

0.01046 to 1.078

0.51

0.047

8

 

Nln

0.71

-0.4190 to 1.832

0.28

0.175

8

 

Btbd12

1.69

0.1775 to 3.198

0.55

0.034

8

 

Zbtb20

0.65

-0.3582 to 1.664

0.29

0.165

8

 

Atf7ip

-

-

-

-

-

  1. The expression of genes in bold text are significantly correlated to expression of Fto (p < 0.05). Genes in cursive text were run on chow fed mice in the 16 hour food restriction paradigm. Hypothalamic expression of Ntrk2 and Bdnf correlate to Fto-expression positively and negatively, respectively, in ad libitum chow fed mice. Pfn2, Stat3 and Btbd12 were positively correlated to expression of Fto in hypothalami of 16 hour food restricted mice.