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Table 1 Candidates genes for FTO-interaction studies based on results from queries in Funcoup, Coxpresdb and IntAct (see Figure 1).

From: Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway

Candidate genes Name Function
PFN2 Profilin 2 Regulates actin polymerization in response to extracellular signals
NRTK2 Neurotrophic tyrosine kinase receptor type 2 Receptor for BDNF
BDNF Brain derived neurotrophic factor involved in neuronal plasticity & differentiation
PRKACB cAMP dependent protein kinase catalytic subunit beta Ser/Thr protein kinase, catalytic subunit of AMP-activated protein kinase (AMPK)
VAMP2 Vesicle-associated membrane protein 2. alt. Synaptobrevin-2 Involved in the targeting and/or fusion of transport vesicles to their target membrane.
STAT3 Signal transducer and activator of transcription 3 Transcription factor involved in cell growth and apoptosis. Responds to leptin signalling.
NLN Neurolysin Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A
BTBD12 SLX4 structure-specific endonuclease subunit homolog DNA-repair, endonuclease activity.
ZBTB20 Zinc finger and BTB domain-containing protein 20 May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses
ATF7IP Activating transcription factor 7-interacting protein A regulator of telomerase reverse transcriptase (TERT) expression
  1. STAT3 was included in our analysis due to previous publications suggesting a link between this gene and FTO [36].