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Table 2 Gene expression of IL-1β, IL-6, TNF-α, CD11B, MMP-9 and GFAP after 2 h of tMCAO and 24 h post-reperfusion

From: Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats

  Vehicle   Solulin  
Gene Contralateral [%] Ipsilateral [%] Contralateral [%] Ipsilateral [%]
IL-1β 100 1165.5 ± 1522.1 46.6 ± 42.8 242.7 ± 443.4
IL-6 100 775.2 ± 724.4 26.1 ± 22.2 411.7 ± 550.6
TNF-α 100 206.2 ± 278.9 86.1 ± 92.4 83.9 ± 56.9
MMP-9 100 257.6 ± 131.1 41.9 ± 46.5 201.6 ± 97.1
CD11B 100 236.2 ± 56.1 86.6 ± 85.5 119.6 ± 102.8
GFAP 100 108.4 ± 69.5 71.7 ± 89.7 87.1 ± 89.7
  1. Gene expression of three consecutive coronal sections of TTC-stained hemispheres. The contralateral non-infarcted hemispheres of the vehicle-treated group acted as internal controls. Values of these hemispheres were therefore set to 100%. All other values (infarcted hemisphere vehicle-treated group, infarcted and non-infarcted hemisphere of the Solulin cohort) were expressed as percentages of the latter. RT-PCR values were normalized to the housekeeping gene HPRT and cyclophilin A. All mRNA levels are given as means ± SD.