CLR/RAMP1 and CGRP double-staining in rat STN. (A) Expression of CLR and RAMP1 in rat STN. The receptor components are found around fiber bundles in the spinal trigeminal tract (arrows) and in the walls of capilliaries (arrow heads). (B, C) Double-staining of CLR (red) and RAMP1 (green). They co-localize in fiber bundles and in fibers spanning from the spinal trigeminal tract (arrows). Arrow heads point at co-expression in the capillaries. (D) CGRP and CLR double-staining, CGRP (red arrows) is mostly expressed in the superficial laminae while CLR (green arrows) is expressed in the spinal trigeminal tract. No co-localization is found.