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Figure 4 | BMC Neuroscience

Figure 4

From: Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats

Figure 4

Anterograde BDA-Labelled Fibres in the Spinal Cord of Liposome-Treated Animals. A) Histology-processed section through the SCI epicentre (black asterisk) revealed extent of lesioning through the dorsal columns (dashed line; shown as insert in panel B). B) Montage of lesion site (black asterisk) demonstrating anterograde BDA-labelled fibres present only in the distal stump of the spinal cord (D), with no visible fibres found in the proximal stump (C). E-G) Closer observation distally revealed extensive neuronal collapse and retraction of BDA-labelled fibres evident by their bulb-like structure (black arrows). BDA = biotinylated dextran amine, DCC = dorsal column cut. Directional key: D = dorsal, V = ventral, C = caudal, R = rostral. Scale bars, A (horizontal bar) 500 μm and (vertical bar) 1 mm, montage B 800 μm, C-E 200 μm, F-G enlarged views 100 μm.

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