Skip to main content

Advertisement

Table 4 Contractile effects of Ang II in MCA

From: Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage

  N K+ mean ±
s.e.m
Emax (%) ±
s.e.m
pEC50 ±
s.e.m
Ang II after PD123319 MCA     
Sham 6 2.34 ± 0.38 3 ± 2a  
SAH 6 1.33 ± 0.28 53 ± 12a,b 7.95 ± 0.38
SAH + SB386023-b at 0 h
SAH + SB386023-b after 6 h
6
6
1, 74 ± 0.11
1.64 ± 0.12
11 ± 4b
13 ± 5b
 
SAH + SB386023-b after 12 h 6 1.47 ± 0.54 35 ± 5 8, 69 ± 0.14
  1. Responses were characterized by Emax values, expressed as percent of 63 mM K+ -induced contraction, and pEC50 values (negative logarithm of the molar concentration that produces half maximum contraction). Values are represented as mean ± s.e.m and n represents number of animal. a = significant difference between SAH and control groups, b = significant difference between SAH and SAH treated with SB386023-b