Effect of treatment with the raf inhibitor SB386023-b in cerebral arteries on the mRNA levels of ET
receptors after experimental induced SAH in rats. (A) ETB, (B) 5-HT1B and (C) AT1. There are upregulations of the ETB, 5-HT1B and AT1 receptor mRNA levels in the SAH compared to the sham operated rats. Treatment with SB386023-b prevented the upregulations. Data were obtained by real-time PCR and are expressed as mean ± s.e.m. values relative to EF-1 mRNA levels, n = 7-10, * P ≤ 0.05. Statistical analyses were performed using Kruskal-Wallis non-parametric test together with Dunn's post-hoc test.