Concentration response curves elicited by cumulative application of ET-1, 5-CT and Ang II in rat cerebral arteries. (A) ET-1; BA, (B) 5-CT; BA, (C) Ang II pretreated with PD123319; MCA and (D) Ang II; MCA. Effect of induced experimental SAH, SAH treated with raf inhibitor SB386023-b at 0 h, 6 h and 12 h after SAH and sham operated rats are illustrated. The responses to ET-1, 5-CT and Ang II (pretreated with PD123319) are clearly increased in the SAH compared to sham operated rats. The effects of SAH are clearly inhibited with use of SB386023-b after 0 and 6 hour. Data are expressed as mean ± s.e.m, * P ≤ 0.05. * significantly difference between SAH and SAH treated with SB386023-b at 0 and 6 h. Statistical analyses were performed using Kruskal-Wallis non-parametric test together with Dunn's post-hoc test.