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Figure 2 | BMC Neuroscience

Figure 2

From: Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice

Figure 2

CIA reduces amyloid plaque burden in APP/PS1 mice. (A) Bright field photomicrographs of brain sections showing amyloid plaques immunolabeled with 4G8 in 6-month-old wild-type mice (Tg-vehicle) and APP/PS1 mice treated with vehicle (Tg+ vehicle) or CIA (Tg+ CIA). Scale bar = 2 mm. (B) Plaque burden was analyzed by measuring areas positive for 4G8 (Tg+ vehicle, n = 3; Tg+ CIA, n = 4) or thioflavine-S (Tg+ vehicle, n = 7; Tg+ CIA, n = 8). (C) ELISA of soluble and insoluble forms of Aβ40 and Aβ42 in combined cortical and hippocampal tissues (Tg+ vehicle, n = 7; Tg+ CIA, n = 8).

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