Figure 1

Auditory dysfunction in caspase-3 deficient mice. (A) Auditory brainstem response (ABR) thresholds to click stimuli at 3 months of age. Casp3^-/- (n = 6) mice had a significantly higher threshold (*, P < 0.05) compared to Casp3^+/- (n = 13) and Casp3^+/+ (n = 5) mice. (B) Distortion product otoacoustic emission (DPOAE). Averages of distortion product 2F1-F2 at F2 frequencies of 10 kHz, 11.3 kHz, and 12.3 kHz were compared at 3 months of age. Casp3^-/- (n = 5) mice had a significantly smaller distortion product (*, P < 0.05) compared to Casp3^+/- (n = 9) and Casp3^+/+ (n = 5) mice.