Motor coordination deficits in Alpk1PB/PB mice. (A) Illustration of tail elevation in the walking Alpk1PB/PB mice. (B) Illustration of feet-clasping behavior in Alpk1PB/PB mice. The Alpk1PB/PBmice exhibited feet-clasping posture (right) compared to normal posture in wild type mice (left) when the tails were suspended. (C) Complete loss of motor coordination in Alpk1PB/PB mice in the rotarod test. Alpk1PB/PBmice failed to stay on the rotating rod even after a four-day consecutive trial. (D-G) Impaired performances of Alpk1PB/PBmice in the dowel test (D), in the hanging wire test (E) and in the footprint test (F and G). *P < 0.05, **P < 0.01, ≥5 per group.