Figure 1

A) Schematic of the control architecture. The controller generates the feedback signal u(t) that triggers an optical signal, which is feedback onto the genetically modified network. The light trigger activates Channelrhodopsin (ChR2) protein embedded into the genetically modified cell membrane resulting in depolarization of the neuron. B) The mean field network activity (top trace) and the raster activity (bottom trace) in absence of optical trigger. C) Network activity when u(t) modulates the light intensity of optical stimulation. D) Network activity when u(t) triggers a light pulse. H: intensity of light; and , where W is the width of the light pulse. Parameters V0, τ, H and W are determined by the controller. The parameters are: V0=-48 mV, τ=8 ms, H=0.9 mW/mm², W=2 ms, a=0.125 mV^-1 and b=7.25.