Group | Treatment | Animal number | Seizure Severity | Afterdischarge duration (s) | Seizure duration (s) | Total no. of stimulations | [LEV]plasma mg/L | Amplitude (μA) |
---|---|---|---|---|---|---|---|---|
 |  | CS1 | - | - | - | - | - | - |
 |  | CS2 | - | - | - | - | - | - |
Control | - | CS3 | - | - | - | - | - | - |
start | Â | CS4 | - | - | - | - | - | - |
 |  | CS5 | - | - | - | - | - | - |
 |  | 3V1 | 3 | 68 | n.d. | 6 | - | 150 |
 |  | 3V2 | 3 | 69 | n.d. | 6 | - | 100 |
 |  | 3V3 | 3 | 8 | n.d. | 6 | - | 350 |
 | Vehicle | 3V4 | 3 | 41 | n.d. | 18 | - | 150 |
 |  | 3V5 | 3 | 71 | n.d. | 20 | - | 150 |
 |  | 3V6 | 3 | 7 | n.d. | 22 | - | 250 |
1 | Â | 3V7 | 3 | 75 | n.d. | 22 | - | 150 |
 |  | 3L1 | 0 | 16 | n.d. | 6 | 19.7 | 450 |
 |  | 3L2 | 3 | 12 | n.d. | 6 | 33.2 | 225 |
 | Levetiracetam | 3L3 | 0 | 14 | n.d. | 6 | 31 | 325 |
 | 40 mg/kg | 3L4 | 1 | 12 | n.d. | 18 | 24 | 350 |
 |  | 3L5 | 0 | 10 | n.d. | 20 | 23.1 | 200 |
 |  | 3L6 | 1 | 11 | n.d. | 22 | 20.1 | 300 |
 |  | 3L7 | 5 | 42 | 20 | 22 | 23.6 | 375 |
 |  | 5V1 | 5 | 46 | 41 | 23 | - | 325 |
 |  | 5V2 | 5 | 127 | 48 | 31 | - | 175 |
 | Vehicle | 5V3 | 5 | 105 | 44 | 36 | - | 225 |
 |  | 5V4 | 5 | 23 | 18 | 42 | - | 400 |
2 | Â | 5V5 | 5 | 122 | 96 | 40 | - | 300 |
 |  | 5L1 | 1 | 37 | n.d. | 23 | 23.3 | 375 |
 | Levetiracetam | 5L2 | 0 | 83 | n.d. | 31 | 24.3 | 125 |
 | 40 mg/kg | 5L3 | 5 | 18 | 10 | 36 | 27 | 325 |
 |  | 5L4 | 3 | 19 | n.d. | 42 | n.d. | 275 |
 |  | 5L5 | 3 | 71 | n.d. | 40 | 18.9 | 250 |
 |  | FV1 | 5 | 95 | 41 | 14 | - | 250 |
 |  | FV2 | 5 | 98 | 42 | 14 | - | 375 |
 | Vehicle | FV3 | 5 | 120 | 55 | 19 | - | 200 |
 |  | FV4 | 5 | 132 | 43 | 22 | - | 150 |
3 | Â | FV5 | 5 | 78 | 59 | 25 | - | 350 |
 |  | FL1 | 5 | 13 | 12 | 14 | 19.6 | 275 |
 | Levetiracetam | FL2 | 1 | 16 | n.d. | 14 | 27.5 | 200 |
 | 40 mg/kg | FL3 | 5 | 12 | 14 | 19 | 39.7 | 500 |
 |  | FL4 | 1 | 9 | n.d. | 22 | 22.6 | 150 |
 |  | FL5 | 5 | 69 | 31 | 25 | 18.5 | 100 |
 |  | CE1 | - | - | - | - | - | - |
 |  | CE2 | - | - | - | - | - | - |
Control | - | CE3 | - | - | - | - | - | - |
end | Â | CE4 | - | - | - | - | - | - |
 |  | CE5 | - | - | - | - | - | - |
 |  | CE6 | - | - | - | - | - | - |