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Table 1 Animal groups, kindling and seizure parameters from the final day of stimulation

From: Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats

Group

Treatment

Animal

number

Seizure

Severity

Afterdischarge

duration (s)

Seizure

duration (s)

Total no. of

stimulations

[LEV]plasma

mg/L

Amplitude

(μA)

  

CS1

-

-

-

-

-

-

  

CS2

-

-

-

-

-

-

Control

-

CS3

-

-

-

-

-

-

start

 

CS4

-

-

-

-

-

-

  

CS5

-

-

-

-

-

-

  

3V1

3

68

n.d.

6

-

150

  

3V2

3

69

n.d.

6

-

100

  

3V3

3

8

n.d.

6

-

350

 

Vehicle

3V4

3

41

n.d.

18

-

150

  

3V5

3

71

n.d.

20

-

150

  

3V6

3

7

n.d.

22

-

250

1

 

3V7

3

75

n.d.

22

-

150

  

3L1

0

16

n.d.

6

19.7

450

  

3L2

3

12

n.d.

6

33.2

225

 

Levetiracetam

3L3

0

14

n.d.

6

31

325

 

40 mg/kg

3L4

1

12

n.d.

18

24

350

  

3L5

0

10

n.d.

20

23.1

200

  

3L6

1

11

n.d.

22

20.1

300

  

3L7

5

42

20

22

23.6

375

  

5V1

5

46

41

23

-

325

  

5V2

5

127

48

31

-

175

 

Vehicle

5V3

5

105

44

36

-

225

  

5V4

5

23

18

42

-

400

2

 

5V5

5

122

96

40

-

300

  

5L1

1

37

n.d.

23

23.3

375

 

Levetiracetam

5L2

0

83

n.d.

31

24.3

125

 

40 mg/kg

5L3

5

18

10

36

27

325

  

5L4

3

19

n.d.

42

n.d.

275

  

5L5

3

71

n.d.

40

18.9

250

  

FV1

5

95

41

14

-

250

  

FV2

5

98

42

14

-

375

 

Vehicle

FV3

5

120

55

19

-

200

  

FV4

5

132

43

22

-

150

3

 

FV5

5

78

59

25

-

350

  

FL1

5

13

12

14

19.6

275

 

Levetiracetam

FL2

1

16

n.d.

14

27.5

200

 

40 mg/kg

FL3

5

12

14

19

39.7

500

  

FL4

1

9

n.d.

22

22.6

150

  

FL5

5

69

31

25

18.5

100

  

CE1

-

-

-

-

-

-

  

CE2

-

-

-

-

-

-

Control

-

CE3

-

-

-

-

-

-

end

 

CE4

-

-

-

-

-

-

  

CE5

-

-

-

-

-

-

  

CE6

-

-

-

-

-

-

  1. n.d., not determined