Table 3 High frequency pathways* identified by KEGG/pathway analysis in clusters 1, 2, and 3
rank | pathway (total gene count) | p-value | count |
|---|---|---|---|
cluster 1 | |||
1 | Glutamate metabolism (26) | 0.0021 | 2 |
2 | D-Glutamine and D-glutamate metabolism (3) | 0.0081 | 1 |
3 | Taurine and hypotaurine metabolism (10) | 0.0266 | 1 |
4 | Pantothenate and CoA biosynthesis (11) | 0.0293 | 1 |
cluster 2 | |||
1 | T cell receptor signaling pathway (95) | 0.0156 | 2 |
2 | Glycosphingolipid biosynthesis - ganglio series (15) | 0.0307 | 1 |
3 | Cell adhesion molecules (CAMs) (151) | 0.0371 | 2 |
cluster 3 | |||
1 | Focal adhesion (187) | 0.0001 | 17 |
2 | Bladder cancer (36) | 0.0001 | 7 |
3 | TGF-beta signaling pathway (81) | 0.0003 | 10 |
4 | Pathways in cancer (313) | 0.0005 | 22 |
5 | Prostate cancer (92) | 0.0008 | 10 |
6 | Small cell lung cancer (92) | 0.0008 | 10 |
7 | ECM-receptor interaction (74) | 0.0028 | 8 |
8 | Glioma (64) | 0.0047 | 7 |
9 | Melanoma (69) | 0.0072 | 7 |
10 | Renal cell carcinoma (69) | 0.0072 | 7 |
11 | PPAR signaling pathway (70) | 0.0078 | 7 |
12 | mTOR signaling pathway (54) | 0.0081 | 6 |
13 | Gap junction (90) | 0.0091 | 8 |
14 | Glycerophospholipid metabolism (46) | 0.0168 | 5 |
15 | MAPK signaling pathway (255) | 0.0200 | 15 |
16 | Non-small cell lung cancer (52) | 0.0273 | 5 |
17 | Pancreatic cancer (71) | 0.0286 | 6 |
18 | GnRH signaling pathway (91) | 0.0296 | 7 |
19 | Adherens junction (73) | 0.0323 | 6 |
20 | Pyruvate metabolism (38) | 0.0351 | 4 |
21 | Regulation of actin cytoskeleton (204) | 0.0357 | 12 |
22 | Leukocyte transendothelial migration (116) | 0.0366 | 8 |
23 | Chronic myeloid leukemia (79) | 0.0449 | 6 |
24 | Glutathione metabolism (42) | 0.0482 | 4 |