Skip to main content
Figure 2 | BMC Neuroscience

Figure 2

From: Intrinsic response of thoracic propriospinal neurons to axotomy

Figure 2

Genetic expression profiles for the top 20 genes up-regulated and down-regulated following spinal transection. The expression profiles illustrate the normalized log2 expression values with low expression values being represented by green and high expression in red. The 20 genes exhibiting the greatest up-or down- regulation were determined by using a 2-way ANOVA comparing the effects of treatment across post-operative survival points. The resulting P values from the main effect ANOVA were Benjamini-Hochberg corrected for multiple testing. Further investigation of the top 20-upregulated genes revealed a majority of them were either involved or associated with immune function and inflammation, or in cell maintenance and survival (Table 2.2). The top 20 genes down-regulated were mainly involved in different aspects of neuron cell biology. As illustrated in this expression profile, the maximal response (up- or down-regulation) is found during the first, three day, post-injury interval (Post 1.1-1.4). As time progresses, gene expression levels begin to wane (Post 2.1-2.4) returning to levels near to that seen in non-injured control animals by 1-month post-injury (Post 4.1-4.2). This overall analysis of the TPS response to a low thoracic injury suggests that the immune and inflammatory response plays a major role in the early post-injury response of TPS neurons.

Back to article page