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Figure 1 | BMC Neuroscience

Figure 1

From: Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways

Figure 1

Chronic agomelatine treatment but not melatonin or S32006 reduced stress-induced increase of glutamate release in the rat P/FC. 15 mM KCl-evoked glutamate and GABA release in rats treated with vehicle (control), subjected to acute FS-stress (Stress), chronically treated with Agomelatine and then subjected to stress (Agomelatine+Stress), S32006 and then subjected to stress (S32006+Stress) or Melatonin and then subjected to stress (Melatonin+Stress). Data are expressed as means ± SEM. * p < 0.01, ** p < 0.001 Newman Keuls post-hoc tests following One-way ANOVA (n = 6-7 rats/group).

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BMC Neuroscience

ISSN: 1471-2202

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