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Figure 2 | BMC Neuroscience

Figure 2

From: Internal representation of hierarchical sequences involves the default network

Figure 2

Fronto-parietal connectivity and sequence representation. The fronto-parietal network interacted more strongly with the default network during tasks that used an internal sequence representation. During scanning, participants responded to learned and novel pairs from a sequenced set and a non-sequenced set (Figure 1). Connectivity depended on the presence or absence of the underlying sequence. (A) Midline areas showed increased connectivity with the right parietal seed during sequence tasks. Functional connectivity was higher during S and IS conditions than P and IP, a positive Sequence by Parietal Seed psycho-physiological interaction. The orange/yellow colored voxels exhibited this interaction in a second-level analysis (p < 0.01). (B) Midline areas also showed increased connectivity with the preSMA seed during sequence tasks. Colored voxels exhibited a positive Sequence by PreSMA Seed psycho-physiological interaction (p < 0.01). (C) Connectivity between the fronto-parietal network and the posterior cingulate was high during sequence tasks S and IS, low during non-sequence tasks P and IP. Right: connectivity between right parietal seed and posterior cingulate from (A). Left: connectivity between PreSMA seed and posterior cingulate from (B). Error bars indicate the standard error of the mean. (D) The midline areas are within the default mode network. The table gives cluster coordinates in the MNI atlas space, corresponding to maps in (A) and (C). Voxels individually were p < 0.001 uncorrected, and reported clusters were significant at p < 0.01 corrected for multiple voxel comparisons based on cluster extent (one-tailed tests). The clusters were located in anterior cingulate, medial frontal gyrus, posterior cingulate, and precuneus, areas associated with the default network.

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