Skip to main content

Table 2 Differentially expressed genes in the RTT frontal cortex (microarray analysis).

From: Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain

GENBANK ACC # GENE NAME GENE SYMBOL CHR FUNCTION UP OR DOWN REGULATED
(average of comparisons)
H14069 Amyloid beta (A4) precursor-like protein 1 APLP1 19q13.1 Enhancer of neuronal apoptosis UP 2.0
SD 0.47
SEM 0.24
W68191 Clusterin
(apolipoprotein J)
CLU 8p21-p12 Extracellular molecular chaperone UP 1.6
SD 0.12
SEM 0.06
H30899 Collapsin response mediator protein 1 CRMP1 4p16.1-p15 Part of semaphorin signal transduction pathway UP 2.6
SD 0.14
SEM 0.08
BE879779
BM888296
BM842146
Cytochrome c oxidase subunit I CO1 M Mitochondrial respiratory chain DOWN 3.3
SD 0.61
SEM 0.27
H51542 Dynamin I DNMI 9q34 Produces microtubule bundles. Binds and hydrolyzes GTP. Vesicular trafficking UP 2.0
SD 0.63
SEM 0.31
BE513417 Echinoderm microtubule associated protein like 2 (Homo sapiens) EML2 19q13.32 Modifies the assembly dynamics of microtubules DOWN 1.9
SD 0.05
SEM 0.02
AL565619 GDP dissociation inhibitor 1 GDI1 Xq28 Regulates the GDP/GTP exchange UP 1.78
SD 0.33
SEM 0.17
H14897 Guanine nucleotide binding protein (G protein), beta polypeptide 1 GNBI 1p36.33 Integrates signals between receptors and effector proteins UP 2.5
SD 0.90
SEM 0.45
BG167084
BM783962
16S ribosomal RNA/Humanin HMN M* Potential role in neurons via a putative cell-surface receptor through which it exhibits neuroprotective activity UP 2.1
SD 0.34
SEM 0.17
R52851 Reticulon 3 RTN3 11q13 Blocks access of BACE1 (Beta-site APP-cleaving enzyme 1) to APP (amyloid precursor protein) within neurons UP 2.5
SD 0.82
SEM 0.41
  1. These genes were differentially expressed in the RTT frontal cortex when compared to expression in the RTT occipital cortex and the control frontal cortex. N.B. The value given for differential expression (either UP or DOWN) refers to the average of the experiments; SD = standard deviation; SEM = standard error of the mean; M = mitochondrial.
  2. * This sequence is 99% identical to 16S ribosomal mitochondrial RNA, and also to some nuclear encoded cDNAs.