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Table 2 Differentially expressed genes in the RTT frontal cortex (microarray analysis).

From: Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain

GENBANK ACC #

GENE NAME

GENE SYMBOL

CHR

FUNCTION

UP OR DOWN REGULATED

(average of comparisons)

H14069

Amyloid beta (A4) precursor-like protein 1

APLP1

19q13.1

Enhancer of neuronal apoptosis

UP 2.0

SD 0.47

SEM 0.24

W68191

Clusterin

(apolipoprotein J)

CLU

8p21-p12

Extracellular molecular chaperone

UP 1.6

SD 0.12

SEM 0.06

H30899

Collapsin response mediator protein 1

CRMP1

4p16.1-p15

Part of semaphorin signal transduction pathway

UP 2.6

SD 0.14

SEM 0.08

BE879779

BM888296

BM842146

Cytochrome c oxidase subunit I

CO1

M

Mitochondrial respiratory chain

DOWN 3.3

SD 0.61

SEM 0.27

H51542

Dynamin I

DNMI

9q34

Produces microtubule bundles. Binds and hydrolyzes GTP. Vesicular trafficking

UP 2.0

SD 0.63

SEM 0.31

BE513417

Echinoderm microtubule associated protein like 2 (Homo sapiens)

EML2

19q13.32

Modifies the assembly dynamics of microtubules

DOWN 1.9

SD 0.05

SEM 0.02

AL565619

GDP dissociation inhibitor 1

GDI1

Xq28

Regulates the GDP/GTP exchange

UP 1.78

SD 0.33

SEM 0.17

H14897

Guanine nucleotide binding protein (G protein), beta polypeptide 1

GNBI

1p36.33

Integrates signals between receptors and effector proteins

UP 2.5

SD 0.90

SEM 0.45

BG167084

BM783962

16S ribosomal RNA/Humanin

HMN

M*

Potential role in neurons via a putative cell-surface receptor through which it exhibits neuroprotective activity

UP 2.1

SD 0.34

SEM 0.17

R52851

Reticulon 3

RTN3

11q13

Blocks access of BACE1 (Beta-site APP-cleaving enzyme 1) to APP (amyloid precursor protein) within neurons

UP 2.5

SD 0.82

SEM 0.41

  1. These genes were differentially expressed in the RTT frontal cortex when compared to expression in the RTT occipital cortex and the control frontal cortex. N.B. The value given for differential expression (either UP or DOWN) refers to the average of the experiments; SD = standard deviation; SEM = standard error of the mean; M = mitochondrial.
  2. * This sequence is 99% identical to 16S ribosomal mitochondrial RNA, and also to some nuclear encoded cDNAs.