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Figure 6 | BMC Neuroscience

Figure 6

From: Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain

Figure 6

Cytochrome c oxidase activity following RNAi-mediated knockdown of MECP2. Cytochrome c oxidase (COX) activity was determined as a first order rate constant and expressed as rate/minute/mg protein, whilst the specific activity of the mitochondrial matrix enzyme citrate synthase (CS) was determined and expressed as nmol/minute/mg protein. COX was normalized to CS activity to take into consideration any variation in mitochondrial numbers, and is expressed as a ratio. Three days post-transfection, when MECP2 knockdown is greatest, cytochrome c oxidase activity is just 60% of that observed in the untreated sample at Day 0 (p = 0.005) and the control sample at Day 3 (p = 0.015). KD = knockdown.

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BMC Neuroscience

ISSN: 1471-2202

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