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Figure 5 | BMC Neuroscience

Figure 5

From: Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α

Figure 5

Anti-apoptotic effects of SDF-1α on 6-OHDA-exposed PC12 cells. A: CXCR4 was expressed in PBS-exposed PC12 cells. Scale bar: 20 μm. B, C: At 6 hours after 6-OHDA exposure, the expression of CXCR4 was remarkably up-regulated on 6-OHDA-exposed PC12 cells (C) compared with PBS-exposed PC12 cells (B). Scale bar: 100 μm. D-H: TUNEL/DAPI staining revealed that the number of apoptotic cells with green-colored, fragmented TUNEL-positive nuclei were reduced in SDF-1α treatment cells (D: 0.1 ng/ml, E: 1 ng/ml, F: 10 ng/ml, G: 50 ng/ml) compared with that of the control cells (H). Scale bar: 100 μm. I: SDF-1α treatment significantly reduced the number of TUNEL-positive 6-OHDA-exposed PC12 cells. *p < 0.05 versus the control with PBS.

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