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Figure 2 | BMC Neuroscience

Figure 2

From: Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α

Figure 2

Preservation of dopaminergic systems of 6-OHDA-lesioned rats by MSC transplantation. A-H: TH-positive fibers in the striatum and neurons in the SNc of rats that received MSC transplantation were markedly preserved (D, H), compared with rats receiving PBS injection (B, F) and fibroblast transplantation (C, G). Normal TH-positive fibers and neurons were recognized in the intact striatum (A) and SNc (E). Scale bar: 100 μm in (A)-(D), 200 μm in (E)-(H). I: The density of TH-positive fibers in the striatum was analyzed with a computerized image analysis system. Rats receiving MSC transplantation showed a significant preservation in the density of TH-positive fibers in the striatum compared with the control rats. *p < 0.05 versus the control groups. J: The number of TH-positive neurons in the SNc was counted. The number of TH-positive neurons in the SNc was also significantly high, compared with the control rats. *p < 0.05 versus the control groups.

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BMC Neuroscience

ISSN: 1471-2202

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