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Figure 4 | BMC Neuroscience

Figure 4

From: N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

Figure 4

NAGly-induced BV-2 microglial migration is G i/o -receptor mediated and can be antagonized. (A) BV-2 microglial migration in response to basal conditions; vh (0.1% DMSO); 1 μM fMLP; 1 μM fMLP + 100 nM SR144528; 1 μM NAGly; 1 μM NAGly + 1 μM SR141716A; 1 μM NAGly + 100 nM SR141716A; 1 μM NAGly + 100 nM SR144528;. ** = P < 0.01 compared to 1 μM NAGly; tt = P < 0.01 compared to 1 μM fMLP; Student's unpaired t-test; n = 3. (B) BV-2 microglial migration in response to 0.1 nM - 10 μM NAGly ± 1 μM O-1918, ± 1 μM ARA-S, or ± 24 h pre-treatment with 1 μg/ml PTX; n = 3.

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