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Table 1 Effects of MK on KA-induced seizure activities

From: Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus

Treatment

(μg/mouse)

Latency to onset

(sec)

Seizure duration

(sec)

Seizure intensity

(maximum score 5.0)

Vehicle

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

KA (0.2) alone

169.9 ± 38.8*

1,200.6 ± 372.3*

4.2 ± 0.1*

+MK (0.1)

160.0 ± 28.5

616.7 ± 50.3#

2.5 ± 0.3#

+MK (0.2)

172.8 ± 33.8

422.4 ± 71.5#

2.2 ± 0.2#

+MK (0.4)

188.8 ± 47.0

318.6 ± 31.7#

1.7 ± 0.3#

  1. Data are presented as mean ± SEM. * p < 0.05, as compared with PBS. # p < 0.05, as compared with KA. Student's t-test.
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BMC Neuroscience

ISSN: 1471-2202

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