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Table 1 Effects of MK on KA-induced seizure activities

From: Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus

Treatment
(μg/mouse)
Latency to onset
(sec)
Seizure duration
(sec)
Seizure intensity
(maximum score 5.0)
Vehicle 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
KA (0.2) alone 169.9 ± 38.8* 1,200.6 ± 372.3* 4.2 ± 0.1*
+MK (0.1) 160.0 ± 28.5 616.7 ± 50.3# 2.5 ± 0.3#
+MK (0.2) 172.8 ± 33.8 422.4 ± 71.5# 2.2 ± 0.2#
+MK (0.4) 188.8 ± 47.0 318.6 ± 31.7# 1.7 ± 0.3#
  1. Data are presented as mean ± SEM. * p < 0.05, as compared with PBS. # p < 0.05, as compared with KA. Student's t-test.