Figure 5

Pattern of cell brain extravasations after successful BBBD. A, C) Accumulation of cells in the proximity of vessels was observed in the BBBD hemisphere. Groups of cells were detected in the sections analyzed (See Methods for Details). B, D) Conversely, fewer cells were detected in the contralateral non-BBBD hemisphere. E-F) A significant number of vessels was associated with cellular extravasates. These vessels were mostly confined to the BBBD hemisphere (F). Cell extravasates were distributed in the immediate proximity of the disrupted vessels (perivascular compartment, red bar in F), while negligible amounts were measured in the parenchyma (not shown).