Figure 5
From: Apolipoprotein-E forms dimers in human frontal cortex and hippocampus
Proportion of apoE present as dimers is significantly lower in heterozygous apoE3/4 AD brain homogenates. The proportion of total apoE present as dimers was compared between homozygous apoE3/3 and heterozygous apoE3/4 frontal cortex homogenates, under non-reduced (NR) and reduced (R) conditions. Western blotting was performed using goat anti-apoE polyclonal antibody. The human brain samples (AD n = 8) are identified according to the Case # code given in Table 1.