Poor performance of SurvivinCamcremice in water maze. Morris water maze studies were performed as detailed in Methods. (A) SurvivinCamcremice (ko) exhibited a significantly longer escape latency as compared to controls (wt) during acquisition of the task (P < 0.001). (B) Representative swim paths of control and SurvivinCamcremice during acquisition training. (C) The mean percent time spent in each quadrant during the 1st probe trial is plotted for both genotypes. In the first probe trial performed after 5 days of training, the control mice already had a preference for the target quadrant compared to adjacent 1 and opposite quadrants, whereas the SurvivinCamcremice had no preference at all. (D, E) In the second probe trial (representative swim path shown in D), control mice spent most of the time in the target quadrant, while SurvivinCamcremice spent equal amounts of time in the target and adjacent 2 quadrant. Open triangle and black dot represent location of the start and the platform, respectively. adj, adjacent 1 or adjacent 2 quadrant; opp, opposite quadrant. Results in panels A, C and E are reflected as means + SEM, n = 12 mice per group. *P < 0.05; **P < 0.001.