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Figure 2 | BMC Neuroscience

Figure 2

From: Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro

Figure 2

Neurite outgrowth analysis of SVZ/RMS-derived neurons using pharmacological treatments. (A) - (F) Examples of neurite outgrowth analysis in SVZ/RMS cultures treated by DMSO (A), PI3K inhibitor LY294002 (B), Akt1 inhibitor X (C), Toxin A of C. difficile (D), Rac1 inhibitor (E) and PKCζ pseudosubstrate inhibitor myristoylated (F) are shown. (G) and (H) All inhibitors decreased the longest neurite length of the Tuj1-positive cells at DIV1 and DIV4, respectively. (G), * - p < 0.05; (H), * - p < 0.001. Abbreviations: Ak - Akt1 inhibitor, C - control, LY - PI3K inhibitor LY294002, PZ - PKCζ inhibitor, Ra - Rac1 inhibitor, TA - Rho GTPases inhibitor Toxin A of C. difficile, Tuj1 - tubulin beta III to label immature neurons, W - PI3K inhibitor wortmannin. Scale bars in main illustrations are 50 μm and 20 μm in insets.

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