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Table 1 Potency and relative efficacy for ATX, DH-ATX, veratridine and PbTx-2-induced sodium influx in rNav1.2, rNav1.4 and rNav1.5 α-subunits

From: Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits

  rNav1.2 rNav1.4 rNav1.5
  EC50(nM) (95% CI) Efficacy EC50(nM) (95% CI) Efficacy EC50(nM) (95% CI) Efficacy
ATX 376.5 (258.5-548.3) 1 164.6 (87.4-309.9) 1 205.1 (155.8-270.1) 1
DH-ATX 1,129 (384.3-3,314) 0.32 644.1 (293.7-1,412) 0.33 595.1 (173.6-2,040) 0.25
Veratridine N/A 0 N/A 0 N/A 0
PbTx-2 N/A 0 N/A 0 N/A 0