Table 1 Potency and relative efficacy for ATX, DH-ATX, veratridine and PbTx-2-induced sodium influx in rNav1.2, rNav1.4 and rNav1.5 α-subunits
rNav1.2 | rNav1.4 | rNav1.5 | ||||
|---|---|---|---|---|---|---|
EC50(nM) (95% CI) | Efficacy | EC50(nM) (95% CI) | Efficacy | EC50(nM) (95% CI) | Efficacy | |
ATX | 376.5 (258.5-548.3) | 1 | 164.6 (87.4-309.9) | 1 | 205.1 (155.8-270.1) | 1 |
DH-ATX | 1,129 (384.3-3,314) | 0.32 | 644.1 (293.7-1,412) | 0.33 | 595.1 (173.6-2,040) | 0.25 |
Veratridine | N/A | 0 | N/A | 0 | N/A | 0 |
PbTx-2 | N/A | 0 | N/A | 0 | N/A | 0 |