Figure 7
Reciprocal allosteric interaction between ATX and neurotoxin site 5 in cells expressing rNa v 1.4 α-subunits. (a), (b), Time-response relationships for PbTx-2 induced sodium influx in the absence and presence of 10 nM of ATX in cells expressing rNav1.4 α-subunits; (c), Concentration-response relationships for PbTx-2-induced sodium influx in the absence and presence of 10 nM of ATX; (d), (e), Time-response relationships for ATX-induced sodium influx in the absence and presence of 3 μM of PbTx-2 in cells expressing rNav1.4 α-subunits; (f), Concentration-response relationships for ATX-induced sodium influx in the absence and presence of 3 μM of PbTx-2. These data were repeated twice in triplicate with similar results.