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Table 1 List of significantly over-expressed genes affected by antidepressants

From: Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray

Clone name (mRNA)

Fold change (log2mean)

Accession number

 

NS

Imip

Fluo

Phen

 

Transforming growth factor, beta 2

1.6 (7)

1.8 (7)

2.0 (7)

2.3 (7)

NM_031131

Growth differentiation factor 15

1.3 (7)

 

1.0 (7)

1.4 (7)

NM_019216

Nerve growth factor, beta

1.0 (3)

1.7 (3)

1.4 (3)

1.7 (3)

XM_001067130

Glial cell line derived neurotrophic factor superfamily receptor alpha 2

1.1 (1)

1.1 (1)

1.0

1.1 (1)

NM_012750

Macrophage expressed gene 1

1.7 (1)

1.4 (1)

1.5 (1)

1.1 (1)

NM_022617

Midkine

  

1.2 (3)

1.4 (3)

NM_030859

Tumor necrosis factor, member 11

 

1.4 (1)

1.3 (1)

 

NM_057149

Type 1 tumor necrosis factor receptor regulator

2.0 (3)

1.7 (3)

1.4 (3)

2.2 (3)

NM_030836

Activity-dependent neuroprotective protein

1.0 (1)

 

1.3 (1)

 

NM_012755

Fyn proto-oncogene

1.1 (1)

 

1.3 (1)

1.1 (1)

NM_012755

Jun D proto-oncogene

 

2.0 (3)

1.7 (3)

1.9 (3)

NM_138875

RAB6A, member RAS oncogene family

 

1.1 (7)

1.0 (7)

 

XM_001062702

Adenosine A1 receptor

 

1.0 (3)

1.0 (3)

1.0 (3)

NM_017155

Neurotrophic tyrosine kinase, receptor, type 2

 

1.0 (3)

1.0 (3)

 

NM_012731

Somatostatin receptor 5

 

1.5 (3)

1.8 (3)

 

NM_012882

Leptin receptor

1.1 (3)

1.2 (3)

1.1 (3)

1.5 (3)

NM_012596

Adrenomedullin

1.2 (3)

 

1.2 (3)

1.1 (3)

NM_012715

Adrenomedullin receptor

1.2 (7)

   

XM_001076934

Arrestin, beta 1

 

1.0 (3)

1.5 (3)

1.3 (3)

NM_012910

Regucalcin

1.3 (7)

1.2 (7)

 

1.9 (7)

NM_031546

Syntaxin 1A (brain)

1.5 (3)

  

1.3 (3)

NM_053788

Syntaxin 11

1.7 (7)

1.6 (7)

1.7 (7)

2.1 (7)

NM_001025638

Epsin 1

1.2 (3)

1.5 (3)

1.6 (3)

1.4 (3)

NM_057136

Caspase 8

 

1.5 (3)

1.8 (3)

1.0 (3)

NM_022277

Cyclin-dependent kinase 5 (p35)

 

1.1 (3)

1.2 (3)

1.1 (3)

NM_053891

Synuclein, alpha

 

1.0 (3)

1.4 (3)

1.4 (3)

NM_019169

Amyloid beta (A4) precursor protein

 

1.0 (3)

1.1 (3)

1.3 (3)

NM_019288

Homogentisate 1, 2-dioxygenase

 

2.4 (7)

 

2.3 (7)

NM_001012145

  1. List of over-expressed genes affected more than 2 fold to their specific control by antidepressant treatments. ( ) indicated the sacrificed day of oral administered rat with antidepressant. NS; Nelumbinis Semen, Imip; imipramine, Fluo; fluoxetine, Phen; phenelzine
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BMC Neuroscience

ISSN: 1471-2202

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