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Table 4 Phenotypic Differences Between Thoracic and Cervical Propriospinal Neurons

From: Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury

      Fold Chg Individual Fold Chg Post hoc P value
Gene Level F Level P FDR ΔΔCp Cerv-Thor Time1 Time2 Time3 Time1 Time2 Time3
Hspb1 159.50 0.00002 0.001 -3.67 12.8 0.9 43.2 50.9 0.9273 0.0426 0.0833
Lifr 142.15 0.00002 0.001 -3.31 9.9 7.2 6.3 21.7 0.062 0.0273 0.0029
Ldha 104.55 0.00005 0.001 3.06 0.1 0.1 0.2 0.1 2E-05 0.0003 0.0062
Rplp1 82.46 0.00010 0.001 -3.55 11.7 10.2 8.9 17.7 6E-06 0.0004 0.0001
Nf1 53.07 0.00030 0.004 -2.29 4.9 1.4 4.0 20.6 0.7123 0.0375 0.0509
Ntf5 52.54 0.00040 0.004 -5.52 46.0 14.5 48.6 138.2 0.0027 0.0139 0.0107
Crhr1 34.54 0.00110 0.009 -5.69 51.5 7.8 88.0 198.9 0.0633 0.0091 0.0073
Gfra2 34.36 0.00110 0.008 -2.54 5.8 1.2 8.8 18.4 0.6241 0.1267 0.0388
Gfra1 26.31 0.00220 0.014 -3.29 9.8 3.8 12.1 20.5 0.3976 0.0122 0.002
HcRt 20.89 0.00380 0.022 -7.96 248.3 29.1 857.7 614.3 0.0049 0.0159 0.0079
Ntrk2 19.49 0.00450 0.024 -0.22 1.2 0.7 1.1 2.2 0.5642 0.9113 0.5394
Zfp110 19.21 0.00470 0.023 -2.74 6.7 2.9 8.5 12.3 0.2716 0.0457 0.1485
Tp53 17.61 0.00570 0.026 -2.49 5.6 5.1 5.5 6.3 0.1686 0.0759 0.1054
Tgfa 16.48 0.00670 0.028 -3.99 15.9 3.5 21.7 53.0 0.0804 0.0008 0.0015
Ntrk1 14.67 0.00870 0.034 -5.98 63.3 19.7 106.5 120.6 0.0049 0.0006 0.0006
Zfp91 14.44 0.00900 0.033 -1.70 3.2 1.4 3.0 8.0 0.5574 0.252 0.0011
Npffr2 13.86 0.00980 0.034 -4.59 24.1 9.3 19.3 78.0 0.0283 0.0038 0.0007
Artn 13.89 0.00980 0.032 -6.97 125.4 21.8 335.2 270.2 0.0017 0.0482 0.0045
Npy1r 13.61 0.01020 0.032 -5.44 43.3 4.9 89.2 184.5 0.1173 0.0017 0.0002
Fgfr1 12.28 0.01280 0.038 -1.33 2.5 1.6 3.4 3.0 0.3199 0.0554 0.1921
Stat1 11.92 0.01360 0.038 -0.54 1.5 0.2 8.0 1.9 0.2964 0.0022 0.7465
Fus 10.51 0.01760 0.047 -1.56 3.0 1.7 2.0 7.3 0.066 0.1028 0.0051
Cntfr 10.26 0.01850 0.047 -0.52 1.4 1.6 0.9 2.2 0.5502 0.8505 0.4669
Npy 10.16 0.01890 0.046 -1.45 2.7 0.9 2.9 8.2 0.8662 0.0062 0.0459
Frs2 9.82 0.02020 0.048 -1.22 2.3 0.8 3.4 4.8 0.8758 0.0124 0.3093
Adcyap1r1 9.22 0.02290 0.052 -4.42 21.5 9.0 27.6 39.9 0.0268 0.0043 9E-05
Hprt 9.22 0.02290 0.050 2.19 0.2 0.2 0.2 0.3 0.0719 0.0575 0.002
Ppyr1 7.79 0.03150 0.066 -6.86 116.2 31.2 69.5 723.5 0.1673 0.0261 0.0019
Tgfb1 7.65 0.03260 0.066 -3.84 14.3 13.9 7.9 26.9 0.0056 0.0095 0.0071
Mt3 6.94 0.03880 0.076 0.14 0.9 0.9 0.9 0.9 0.7328 0.4609 0.8946
Rpl13a 6.27 0.04630 0.088 -1.66 3.2 4.4 3.1 2.3 0.0223 0.0435 0.0002
  1. Phenotypic differences between Thoracic and Cervical Propriospinal neurons. Significant differences in gene expression between LDPT and TPS neurons were detected using a 2 way ANOVA (shown in bold at Time 1, 1-week; Time 2, 2-weeks; and Time 3, 4-weeks post-FG injection). Genes were analyzed for a significant effect of level. P-values were then corrected for multiple testing, by applying the Benjamini-Hochberg FDR algorithm. A Welch's t-test, was used to determine at which specific time-point the difference in gene expression was significant. In the table above 2E-05 represents P values of 2 × 10-5 and 2 E-06 represents a P value of 2 × 10-6. Significant post-hoc P values are shown in italics.