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Table 3 Genes Exhibiting Significant Change in Expression Post-Axotomy

From: Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury

Gene Treat F Treat P Treat FDR Time F Time P Time FDR Intx F Intx P Intx FDR Gene Name
Tgfb1 39.26 0.0008 0.012 0.37 0.7775 0.975 0.29 0.8294 0.959 Transforming growth factor beta-1
Gfra2 58.9 0.0006 0.013 18.01 0.0041 0.182 5.2 0.0537 0.478 GDNF family receptor alpha-2
Artn 53.09 0.0008 0.014 2.46 0.1782 0.721 3.22 0.1205 0.564 Artemin
Tgfbr1 23.1 0.0005 0.015 11.2 0.0011 0.098 17.34 0.0002 0.018 TGF-beta receptor type-1
Crhr1 39.2 0.0015 0.017 0.94 0.489 0.907 0.92 0.4934 0.878 Corticotropin-releasing factor receptor 1
Npffr2 40.59 0.0014 0.018 3.18 0.1223 0.544 0.47 0.7164 0.996 Neuropeptide FF receptor 2 (G-protein coupled receptor 74)
Ntf5 166.32 0.0002 0.018 17.61 0.0091 0.162 14.58 0.0128 0.163 Neurotrophin 4/5
Nrap 17.68 0.0023 0.019 1.13 0.3895 0.889 3.53 0.0618 0.458 Nebulin-related-anchoring protein
Adcyap1r1 32.85 0.0023 0.02 3.25 0.1185 0.555 0.84 0.5267 0.868 Pituitary adenylate cyclase-activating polypeptide type I receptor
HcRt 63.71 0.0005 0.022 8.2 0.0224 0.285 1.89 0.2498 0.717 Orexin (Hypocretin)
Npy1r 29.78 0.0055 0.038 17.98 0.0087 0.194 19.13 0.0078 0.116 Neuropeptide Y receptor type 1
Gfra3 22.14 0.0053 0.039 0.85 0.5251 0.935 9.31 0.0173 0.192 GDNF family receptor alpha-3
Frs2 19.94 0.0066 0.042 17.85 0.0042 0.125 21.47 0.0028 0.083 Fibroblast growth factor receptor substrate 2
Grpr 17.86 0.0083 0.043 0.32 0.8116 0.976 0.71 0.5889 0.92 Gastrin-releasing peptide receptor
Gfra1 16.98 0.0092 0.045 0.34 0.8009 0.976 0.39 0.767 0.922 GDNF family receptor alpha-1
Ntf3 24.74 0.0076 0.045 1.72 0.301 0.893 4.94 0.0785 0.466 Neurotrophin-3
Ntrk1 23.83 0.0081 0.045 8.06 0.0359 0.32 0.45 0.7318 0.972 High affinity nerve growth factor receptor (Trk-A)
Cckar 15.25 0.0113 0.053 0.96 0.4787 0.906 0.46 0.7241 0.991 Cholecystokinin type A receptor
Pycard 9.5 0.0151 0.058 0.52 0.6783 1 1.69 0.2448 0.726 PYD and CARD domain-containing protein
Casp2 9.48 0.0132 0.059 1.38 0.3117 0.895 1.44 0.2955 0.797 Caspase-2
Hspb1 13.15 0.0151 0.061 4.16 0.0794 0.471 15.58 0.0057 0.127 Heat-shock protein 27
Tgfa 11.48 0.0147 0.062 0.31 0.8191 0.959 1.99 0.2174 0.774 Transforming growth factor alpha
Stat4 9.45 0.0218 0.081 0.28 0.8397 0.934 0.08 0.9705 0.993 Signal transducer and activator of transcription 4
Galr2 7.47 0.0257 0.088 4.63 0.037 0.299 1.08 0.4106 0.937 Galanin receptor type 2
Nrg2 6.98 0.0247 0.088 1.19 0.364 0.926 0.61 0.6221 0.955 Pro-neuregulin-2, membrane-bound isoform
Il1b 11.62 0.0271 0.089 2.78 0.1742 0.738 0.91 0.5119 0.876 Interleukin-1 beta
  1. P values for genes exhibiting a significant or nominally significant change in expression post-axotomy. Significant changes in gene expression post-transection were detected using a 2 way ANOVA. As illustrated above, genes were analyzed for a significant effect of treatment (Treat), Time (Time), and Interaction of Treatment and Time (Intx). P-values were then corrected for multiple testing applying the Benjamini-Hochberg FDR algorithm, and are arraigned in order of increasing FDR values based on treatment