Effect of GPR3 KO on brain Aβ levels in young mice. Panel A - Aβ42 was assayed in brain extracts from ten GPR3 wild type (GPR3+/+), ten heterozygous (GPR3+/-), and ten homozygous GPR3 KO (GPR3-/-) mice. Brain Aβ42 was also determined in BACE1, BACE2 homozygous double KO (B1/2 dKO) and wild type (BACE+/+) control mice. Bars represent the mean values. Panel B - the same brain extracts were assayed for Aβ40. Panel C - the same brain extracts were assayed for Aβ1-x.