Changes in uMtCK (A), BCK (B) and CRT (C) immunoreactivity in the hippocampus of chronic epilepsy rat. uMtCK immunoreactivity is markedly reduced in CA1-3 pyramidal cells and hilar neurons due to massive neuronal loss. In contrast, BCK immunoreactivity is similar to that observed in control animals. CRT immunoreactivity is markedly reduced in CA3 pyramidal cells. However, CRT immunoreactivity is detected in reactive astrocytes within the hippocampus. Rectangles in panels 1 indicate the regions of panels 2 and 3. Bar = 200 (panel 1) and 25 (panels 2-4) μm. (D-E) Double immunofluoresent staining for GFAP (green) and CRT (red) in the CA1 subfield of non-SE (D) and chronic epileptic rats (E). Arrows indicate the colocalization of CRT and GFAP immunoreactivity. Bar = 50 μm.