Figure 2

p75^NTR expression in BrdU-positive SGZ cells, 2 hours and 2 days post-BrdU injection. Dentate gyrus coronal sections harvested from p75^NTR (+/+) mice 2 hours or 2 days after a single BrdU injection were co-immunostained with antibodies against BrdU (red) and p75^NTR (green). Stereological estimates (as described in Methods) were used to quantitate the total number of BrdU-positive cells per dentate gyrus (open triangles) and BrdU-positive cells expressing p75^NTR (closed circles) (*** p < 0.001, Student-Newman-Keuls test after ANOVA, n = 6 mice with right and left dentate gyri averaged for each mouse). Scale bar: 200 μm.